DPD symptoms will be monitored through weekly self-report questionnaires as well clinical ratings with a doctor. All patients will receive active treatment. The investigators are testing whether TMS can treat Depersonalization Disorder (DPD). TMS is a procedure that involves 30-minute-long daily sessions every weekday for a series of weeks. TMS applies a magnetic field to the brain for a brief period. This study is a research trial of an outpatient, non-medication, non-invasive investigational treatment called Transcranial Magnetic Stimulation (TMS). The purpose of this study is to evaluate the clinical efficacy of transcranial magnetic stimulation in the treatment of Depersonalization Disorder (DPD). Principal investigator: Antonio Mantovani, MD Title: Treatment of Depersonalization Disorder With Transcranial Magnetic Stimulation (TMS) The scientists suggest that this protein might be a focus for further research into potential treatments.ĭepersonalization/Derealization Disorder Research The researchers also identified a particular protein that seemed to generate the triggering brain activity. Experiments on mice and an epileptic patient who experienced dissociative episodes appeared to identify a pattern of electrical brain activity associated with the episodes. Researchers hope that identifying a neurological mechanism underlying the experience of dissociation may lead to more effective treatment of all these disorders.Ī recent study at Stanford University attempted to look for patterns of brain activity that may be associated with dissociative episodes. Dissociation is at the heart of DPDR and other dissociative disorders, and it plays a role in some other neurological conditions such as epilepsy. Scientists don’t understand precisely what is happening in the brains of people who experience dissociation, a feeling of being disconnected from a sense of self. PLEASE CONSULT A PHYSICIAN FOR MORE INFORMATION.ĭepersonalization/Derealization Disorder Brain Science The symptoms cause the patient distress and/or impair the patient’s daily functioning.The patient understands that the symptoms are not real.The patient has recurring and/or persistent depersonalization and/or derealization symptoms.The disorder’s diagnostic criteria include: Imaging scans or electroencephalogram (EEG) to look for brain abnormalities or physical conditions such as seizure disorders.Blood or urine tests to look for possible causes such as substance abuse.Psychiatric exams to compare the patient’s symptoms to the diagnostic criteria for DPDR.Physical exams and medical histories to look for underlying neurological or physical problems that may be triggering the symptoms.Instead, to diagnose the disorder, medical doctors and mental health professionals will work together on several diagnostic steps to rule out other possible causes for the symptoms and confirm a DPDR diagnosis. There are no tests or exams that can definitively identify DPDR. How Is Depersonalization/Derealization Disorder Diagnosed? Having a sense that things around you are distorted or obscured by a fog.Feeling disconnected from the people and things around you as if a transparent wall separates you.Feeling as if your surroundings are part of a dream or a movie.Feeling as if your memories may not be your own.Feeling as if you’re observing your body, actions, and thoughts from an outside perspective.Feeling as if you’re out of control of your actions or as if you’re a robot.Feeling detached from your body or having a sense that your body is distorted.Some people with DPDR experience constant symptoms for many years at a timeĭPDR symptoms can be divided into depersonalization and derealization categories. Episodes may be as short as a few hours or, in some cases, may last for years. Symptoms usually occur as episodes that come and go. Symptoms of DPDRĭPDR symptoms vary from case to case. All of the disorders feature a disconnection between thoughts, memories, and the outside world. Other conditions in the category include dissociative amnesia, dissociative fugue, and dissociative identity disorder. They may also feel disconnected from other people around them and the outside world in general.ĭPDR is one of a group of disorders known as dissociative disorders. What is Depersonalization/Derealization Disorder?ĭepersonalization/derealization disorder (DPDR) is a mental health condition in which people feel disconnected from their bodies or sense of self.
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